SCHEMBL3719448

SCHEMBL3719448

CC(C)(C)c1cnc(CCC(=O)O)o1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXRA P19793 4/20 0.51
RXRB P28702 4/20 0.51
RXRG P48443 4/20 0.51
NR1H4 Q96RI1 2/20 0.48
CDK2 P24941 10/20 0.42
CCNE2 O96020 9/20 0.42
CCNE1 P24864 9/20 0.42
CDK4 P11802 4/20 0.42
CCND1 P24385 4/20 0.42
CCNB2 O95067 4/20 0.42
CDK1 P06493 4/20 0.42
CCNB1 P14635 4/20 0.42
CCNB3 Q8WWL7 4/20 0.42
CCND3 P30281 4/20 0.42
CCND2 P30279 1/20 0.42
HDAC3 O15379 3/20 0.40
HDAC4 P56524 3/20 0.40
CDK6 Q00534 3/20 0.40
HDAC1 Q13547 3/20 0.40
HDAC7 Q8WUI4 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3718311 0.90 RXRA (0.42) RXRARXRBRXRGNR1H4CDK2
SCHEMBL4632525 0.79 RXRA (0.54) RXRARXRBRXRGNR1H4CDK2
SCHEMBL13189035 0.76 HDAC1 (0.42) CDK2CCNE2CCNE1CDK4CCND1
SCHEMBL13827907 0.76 CDK2 (0.44) CDK2CCNE2CCNE1CDK4CCND1
SCHEMBL3467447 0.74 CDK2 (0.43) CDK2CCNE2CCNE1CDK4CCND1
SCHEMBL1786450 0.74 CDK2 (0.46) CDK2CCNE2CCNE1CDK4CCND1
SCHEMBL21325489 0.74 CDK2 (0.43) CDK2CCNE2CCNE1CDK4CCND1
SCHEMBL3715500 0.74 CYP1A2 (0.39) CDK2CCNE2CCNE1CDK4CCND1
SCHEMBL17328441 0.74 CDK2 (0.43) CDK2CCNE2CCNE1CDK4CCND1
SCHEMBL5724749 0.74 CDK2 (0.45) CDK2CCNE2CCNE1CDK4CCND1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010100144-A1 FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE MERCK SERONO S.A. (CH) 2010-09-10 WO disclosed
WO-2010100144-A1 FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE MERCK SERONO S.A. (CH) 2010-09-10 WO disclosed