Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 14/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 13/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 6/20 | 0.43 |
| ▸ | CDK1 | P06493 | 6/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 6/20 | 0.43 |
| ▸ | CDK4 | P11802 | 6/20 | 0.43 |
| ▸ | CCND1 | P24385 | 6/20 | 0.43 |
| ▸ | CCND3 | P30281 | 4/20 | 0.43 |
| ▸ | CCND2 | P30279 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.39 |
| ▸ | CDK7 | P50613 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | CCNH | P51946 | 2/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.39 |
| ▸ | CIT | O14578 | 1/20 | 0.39 |
| ▸ | CASK | O14936 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22515418 | 0.85 | CDK2 (0.33) | CDK2CCNE1CCNE2CCNB2CDK1 | |
| SCHEMBL22723848 | 0.78 | CCNE1 (0.40) | CDK2CCNE1CCNE2CDK4CCND1 | |
| SCHEMBL19203773 | 0.77 | CDK2 (0.50) | CDK2CCNE1CCNE2CCNB2CDK1 | |
| SCHEMBL5724749 | 0.75 | CDK2 (0.45) | CDK2CCNE1CCNE2CCNB2CDK1 | |
| SCHEMBL6224590 | 0.74 | CDK2 (0.49) | CDK2CCNE1CCNE2CCNB2CDK1 | |
| SCHEMBL3719448 | 0.74 | RXRA (0.51) | CDK2CCNE1CCNE2CCNB2CDK1 | |
| Hydrochloric Acid SCHEMBL5757732 | 0.72 | CDK2 (0.41) | CDK2CCNE1CCNE2CCNB2CDK1 | |
| SCHEMBL1786450 | 0.72 | CDK2 (0.46) | CDK2CCNE1CCNE2CCNB2CDK1 | |
| SCHEMBL5346225 | 0.72 | L3MBTL1 (0.46) | CDK2CCNE1CCNE2CCNB2CDK1 | |
| SCHEMBL20583110 | 0.71 | CDK2 (0.40) | CDK2CCNE1CCNE2CCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627631-B1 | PYRROLIDINONES AS METAP2 INHIBITORS | MERCK PATENT GMBH (DE) | 2015-12-16 | — | — | EP | claimed |