Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 4/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.35 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.35 |
| ▸ | KHK | P50053 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3723926 | 0.90 | IRAK4 (0.47) | IRAK4ALKMETJAK2FLT3 | |
| SCHEMBL17287917 | 0.87 | MET (0.42) | IRAK4METFLT3MAP3K5IRAK1 | |
| SCHEMBL3723366 | 0.84 | MET (0.49) | IRAK4ALKMETMKNK1MKNK2 | |
| SCHEMBL3722850 | 0.84 | ALK (0.45) | IRAK4ALKMETMKNK1MKNK2 | |
| SCHEMBL3722316 | 0.83 | ACVR1B (0.43) | IRAK4METMKNK1MKNK2IRAK1 | |
| SCHEMBL3728635 | 0.82 | ALK (0.43) | IRAK4ALKMETMKNK1MKNK2 | |
| SCHEMBL3724847 | 0.75 | ACVR1B (0.44) | ALKMETMKNK1MKNK2IRAK1 | |
| SCHEMBL3663869 | 0.74 | GRM5 (0.36) | — | |
| SCHEMBL3718389 | 0.73 | MAP4K3 (0.53) | IRAK4ALKMETJAK2FLT3 | |
| SCHEMBL3715497 | 0.73 | IRAK4 (0.48) | IRAK4ALKMETIRAK1MAP4K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242742-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2015-12-02 | — | — | EP | disclosed |
| US-8343966-B2 | Organic compounds | NOVARTIS AG (CH) | 2013-01-01 | — | — | US | disclosed |
| EP-2242742-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009087212-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2009-07-16 | — | — | WO | disclosed |