Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.47 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.47 |
| ▸ | MAP4K3 | Q8IVH8 | 7/20 | 0.45 |
| ▸ | MET | P08581 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3719655 | 0.90 | IRAK4 (0.43) | IRAK4IRAK1MAP4K3METFLT3 | |
| SCHEMBL17287917 | 0.87 | MET (0.42) | IRAK4IRAK1MAP4K3METFLT3 | |
| SCHEMBL3718389 | 0.84 | MAP4K3 (0.53) | IRAK4IRAK1MAP4K3METFLT3 | |
| SCHEMBL3715497 | 0.84 | IRAK4 (0.48) | IRAK4IRAK1MAP4K3METPAK1 | |
| SCHEMBL3722316 | 0.83 | ACVR1B (0.43) | IRAK4IRAK1METPIM1 | |
| SCHEMBL3719529 | 0.82 | MAP4K3 (0.47) | IRAK4IRAK1MAP4K3METPAK1 | |
| SCHEMBL3716555 | 0.79 | NTRK1 (0.57) | IRAK4IRAK1MAP4K3METPAK1 | |
| SCHEMBL3723604 | 0.76 | ABL1 (0.46) | — | |
| SCHEMBL3724847 | 0.75 | ACVR1B (0.44) | IRAK1METALKPIM1 | |
| SCHEMBL3717523 | 0.74 | MET (0.48) | METFLT3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242742-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2015-12-02 | — | — | EP | disclosed |
| US-8343966-B2 | Organic compounds | NOVARTIS AG (CH) | 2013-01-01 | — | — | US | disclosed |
| EP-2242742-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2010-10-27 | — | — | EP | disclosed |
| US-20090215776-A1 | Organic compounds | ADCOCK CLAIRE | 2009-08-27 | — | — | US | disclosed |
| WO-2009087212-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2009-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215776-A1 | Organic compounds | REN, RXFP1, MYLK | IRAK4 569/4885IRAK1 356/4885MAP4K3 3134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.