Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 10/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | PIM1 | P11309 | 8/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.55 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.55 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3719743 | 1.00 | MALT1 (0.67) | MALT1KCNH2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3727537 | 0.93 | MALT1 (0.76) | MALT1KCNH2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2763440 | 0.86 | MALT1 (0.67) | MALT1KCNH2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL612448 | 0.83 | MALT1 (0.64) | MALT1KCNH2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL24441136 | 0.76 | MALT1 (1.00) | MALT1KCNH2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL24441137 | 0.76 | MALT1 (1.00) | MALT1KCNH2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL12368893 | 0.75 | MET (0.50) | MALT1KCNH2PIM1JAK2CDK2 | |
| SCHEMBL2945956 | 0.75 | PIM1 (0.76) | KCNH2PIM1MKNK1 | |
| SCHEMBL3037771 | 0.74 | PIM1 (0.60) | MALT1KCNH2PIM1JAK2CDK2 | |
| SCHEMBL3033386 | 0.74 | PIM1 (0.60) | MALT1KCNH2PIM1JAK2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393790-A1 | DERIVATIVES OF 6-(6-O-CYCLOALKYL OR 6-NH-CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS | SANOFI (FR) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089506-A1 | DERIVATIVES OF 6-(6-O-CYCLOALKYL OR 6-NH-CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2010-08-12 | — | — | WO | disclosed |