Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 2/20 | 0.31 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | VHL | P40337 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830746 | 0.79 | RAB9A (0.38) | RAB9ANPC1PDE10AMAPK1SMN1; SMN2 | |
| SCHEMBL3713266 | 0.78 | RAB9A (0.35) | RAB9ANPC1PDE10AMAPK1SMN1; SMN2 | |
| SCHEMBL13189195 | 0.74 | TRPM8 (0.32) | ELANETRPM8 | |
| Hydrochloric Acid SCHEMBL3711528 | 0.73 | TRPM8 (0.31) | ELANETRPM8 | |
| SCHEMBL2837212 | 0.73 | RAB9A (0.34) | RAB9ANPC1PDE10ASMN1; SMN2CYP2C19 | |
| SCHEMBL3710262 | 0.71 | HPGD (0.38) | RAB9ASMN1; SMN2CYP2D6CYP2C19KMT2A | |
| SCHEMBL3706354 | 0.70 | PIK3CG (0.33) | RAB9APDE10A | |
| SCHEMBL3710825 | 0.69 | HDAC4 (0.32) | RAB9A | |
| SCHEMBL3714063 | 0.69 | HDAC4 (0.33) | RAB9A | |
| SCHEMBL26548064 | 0.68 | CHRM2 (0.35) | ELANETRPM8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |