Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.50 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.50 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 4/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7457012 | 0.84 | GRM4 (0.53) | TLR7PDE10AKDM4EALDH1A1GAA | |
| SCHEMBL5583848 | 0.82 | ALDH1A1 (0.66) | EGLN2FTOKDM4EALDH1A1GAA | |
| SCHEMBL14284346 | 0.82 | ALDH1A1 (0.66) | EGLN2FTOKDM4EALDH1A1GAA | |
| SCHEMBL7457007 | 0.81 | KDM4E (0.48) | PDE10AKDM4EALDH1A1GAAGRM4 | |
| SCHEMBL14159861 | 0.81 | KDM4E (0.50) | EGLN2FTOTLR7KDM4EALDH1A1 | |
| SCHEMBL26856718 | 0.80 | ADORA2A (0.46) | PDE10AKDM4EALDH1A1GAAGRM4 | |
| SCHEMBL21490080 | 0.79 | SMYD3 (0.51) | EGLN2FTOTLR7KDM4EALDH1A1 | |
| SCHEMBL19701397 | 0.79 | SMYD3 (0.51) | EGLN2FTOTLR7KDM4EALDH1A1 | |
| SCHEMBL14159695 | 0.76 | EGLN2 (0.45) | EGLN2FTOTLR7KDM4EALDH1A1 | |
| SCHEMBL23575882 | 0.75 | SMYD3 (0.65) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010131145-A1 | CYCLOBUTENEDIONE DERIVATIVES | PFIZER LIMITED (GB) | 2010-11-18 | — | — | WO | disclosed |