Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | F13A1 | P00488 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | BLM | P54132 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | SPR | P35270 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14756946 | 0.87 | KDM4E (0.73) | KDM4EF13A1ALDH1A1MAPTHPGD | |
| SCHEMBL3726453 | 0.86 | KDM4E (0.63) | KDM4EF13A1ALDH1A1MAPTHPGD | |
| SCHEMBL761158 | 0.85 | KDM4E (0.61) | KDM4EF13A1ALDH1A1MAPTHPGD | |
| SCHEMBL5446259 | 0.83 | KDM4E (0.55) | KDM4EF13A1ALDH1A1MAPTMTNR1A | |
| SCHEMBL734658 | 0.83 | KDM4E (1.00) | KDM4EF13A1ALDH1A1MAPTHPGD | |
| SCHEMBL3724115 | 0.83 | KDM4E (0.58) | KDM4EF13A1ALDH1A1MAPTHPGD | |
| SCHEMBL3720745 | 0.82 | KDM4E (0.51) | KDM4EF13A1ALDH1A1MAPTHPGD | |
| SCHEMBL3719877 | 0.81 | SMN1; SMN2 (0.74) | KDM4EMAPTLMNAMTNR1AMTNR1B | |
| SCHEMBL3727291 | 0.81 | KDM4E (0.50) | KDM4EF13A1ALDH1A1MAPTHPGD | |
| SCHEMBL3720092 | 0.81 | KDM4E (0.50) | KDM4EF13A1ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |