Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29098922 | 0.87 | HPGD (0.50) | HPGDTSHRLMNARAB9ASMN1; SMN2 | |
| SCHEMBL29098918 | 0.85 | SMN1; SMN2 (0.45) | HPGDTSHRLMNARAB9ASMN1; SMN2 | |
| SCHEMBL4704298 | 0.83 | MAPK1 (0.43) | HPGDTSHRLMNASMN1; SMN2KMT2A | |
| SCHEMBL182753 | 0.83 | TSHR (0.56) | HPGDTSHRLMNARAB9ASMN1; SMN2 | |
| SCHEMBL31096231 | 0.83 | TSHR (0.56) | HPGDTSHRLMNARAB9ASMN1; SMN2 | |
| SCHEMBL29098920 | 0.83 | SMN1; SMN2 (0.45) | HPGDS1PR1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL12144470 | 0.81 | AAK1 (0.42) | SLC6A4HRH4 | |
| SCHEMBL16961147 | 0.81 | L3MBTL1 (0.50) | HPGDTSHRS1PR1RAB9ASMN1; SMN2 | |
| SCHEMBL4573180 | 0.80 | KDM4E (0.41) | TSHRSMN1; SMN2HRH4TDP1KDM4E | |
| SCHEMBL30011026 | 0.80 | KDM4E (0.41) | TSHRSMN1; SMN2HRH4TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |