Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3725420 | 0.86 | HSD17B10 (0.50) | MEN1KMT2AL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL3718078 | 0.83 | HRH4 (0.54) | MEN1KMT2AL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL3720912 | 0.83 | MAPT (0.49) | MEN1KMT2AL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL3720247 | 0.80 | SCN9A (0.56) | MEN1KMT2AL3MBTL1ALDH1A1HSD17B10 | |
| SCHEMBL3728038 | 0.79 | HRH4 (0.50) | MEN1KMT2AL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL3727042 | 0.79 | DRD2 (0.47) | L3MBTL1ALDH1A1MAPK1HSD17B10TP53 | |
| SCHEMBL3719607 | 0.79 | ALDH1A1 (0.50) | MEN1KMT2AL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL3717768 | 0.77 | KDM4E (0.57) | MEN1KMT2AALDH1A1MAPK1HSD17B10 | |
| SCHEMBL3728861 | 0.74 | MAPT (0.54) | MEN1KMT2AALDH1A1KDM4EGAA | |
| SCHEMBL3726500 | 0.73 | TSHR (0.50) | MEN1KMT2AALDH1A1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |