Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TCF4 | P15884 | 2/20 | 0.81 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.76 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.74 |
| ▸ | POLB | P06746 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.60 |
| ▸ | WDR5 | P61964 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL788335 | 0.90 | TCF4 (0.66) | TCF4CTNNB1ALDH1A1CYP19A1POLB | |
| SCHEMBL3551591 | 0.89 | ALDH1A1 (0.65) | TCF4CTNNB1ALDH1A1CYP19A1POLB | |
| SCHEMBL16116951 | 0.89 | TCF4 (1.00) | TCF4CTNNB1ALDH1A1CYP19A1POLB | |
| SCHEMBL2823113 | 0.88 | TCF4 (0.67) | TCF4CTNNB1ALDH1A1CYP19A1MEN1 | |
| SCHEMBL788025 | 0.88 | PFKFB3 (0.77) | TCF4CTNNB1ALDH1A1CYP19A1POLB | |
| SCHEMBL6834499 | 0.86 | TCF4 (0.72) | TCF4CTNNB1ALDH1A1CYP19A1POLB | |
| SCHEMBL13532190 | 0.86 | MEN1 (0.71) | TCF4CTNNB1ALDH1A1MEN1KMT2A | |
| SCHEMBL11025715 | 0.85 | POLB (0.78) | TCF4CTNNB1ALDH1A1POLBMEN1 | |
| SCHEMBL6833462 | 0.84 | TCF4 (0.69) | TCF4CTNNB1ALDH1A1CYP19A1POLB | |
| SCHEMBL6833460 | 0.84 | TCF4 (0.69) | TCF4CTNNB1ALDH1A1CYP19A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015016293-A1 | (BENZENESULFONYLAMINO)BENZAMIDE DERIVATIVE, AND SHIP2 INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT | 国立大学法人 富山大学 (JP) | 2015-02-05 | — | — | WO | disclosed |
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |