Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 3/20 | 0.52 |
| ▸ | TYK2 | P29597 | 2/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 7/20 | 0.50 |
| ▸ | MMP2 | P08253 | 6/20 | 0.50 |
| ▸ | MMP8 | P22894 | 6/20 | 0.50 |
| ▸ | MMP9 | P14780 | 5/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188455 | 0.94 | JAK1 (0.56) | JAK1TYK2JAK2JAK3GSK3B | |
| SCHEMBL3714493 | 0.89 | JAK1 (0.53) | JAK1TYK2JAK2JAK3MMP13 | |
| SCHEMBL3718122 | 0.89 | MOK (0.48) | MMP13MMP2MMP8MMP9 | |
| SCHEMBL3710064 | 0.87 | KDM4E (0.48) | MMP13MMP2MMP8MMP9 | |
| SCHEMBL3714015 | 0.86 | JAK2 (0.44) | JAK2JAK3MMP13MMP2MMP8 | |
| SCHEMBL13187726 | 0.85 | ALK (0.45) | MMP13MMP2MMP8 | |
| SCHEMBL3713257 | 0.84 | MMP2 (0.42) | JAK2JAK3MMP13MMP2MMP8 | |
| SCHEMBL3716618 | 0.83 | MMP2 (0.48) | MMP13MMP2MMP8MMP9 | |
| SCHEMBL13187912 | 0.82 | HDAC1 (0.41) | JAK2JAK3MMP13MMP2MMP8 | |
| SCHEMBL13188579 | 0.81 | HDAC1 (0.42) | MMP13MMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |