Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | MMP8 | P22894 | 2/20 | 0.48 |
| ▸ | MMP13 | P45452 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3721164 | 0.89 | PARP1 (0.47) | MMP2MMP8MMP13 | |
| SCHEMBL3715918 | 0.88 | MAPK1 (0.45) | MMP2MMP8MMP13 | |
| SCHEMBL3718122 | 0.85 | MOK (0.48) | MMP2MMP8MMP13HDAC1HDAC3 | |
| SCHEMBL3714253 | 0.85 | HDAC1 (0.52) | MMP2MMP8MMP13HDAC1HDAC3 | |
| SCHEMBL3716614 | 0.84 | HDAC1 (0.49) | MMP2MMP8MMP13HDAC1HDAC3 | |
| SCHEMBL3712338 | 0.83 | MMP2 (0.51) | MMP2MMP8MMP13MMP9 | |
| SCHEMBL3720519 | 0.83 | JAK1 (0.52) | MMP2MMP8MMP13MMP9 | |
| SCHEMBL3713800 | 0.83 | HDAC1 (0.44) | MMP2MMP8MMP13HDAC1 | |
| SCHEMBL3714015 | 0.82 | JAK2 (0.44) | MMP2MMP8MMP13HDAC1HDAC3 | |
| SCHEMBL13187726 | 0.82 | ALK (0.45) | MMP2MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |