Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 19/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 18/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.55 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.55 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3722010 | 0.93 | MTOR (0.63) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3725356 | 0.88 | MTOR (0.68) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3722933 | 0.85 | MTOR (0.55) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3718679 | 0.85 | MTOR (0.59) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3718816 | 0.84 | MTOR (0.58) | MTORPIK3CAPIK3CG | |
| SCHEMBL3722987 | 0.83 | MTOR (0.60) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3719933 | 0.83 | MTOR (0.69) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3721937 | 0.80 | MTOR (0.59) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL1430506 | 0.80 | PIK3CA (0.84) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3721950 | 0.78 | MTOR (0.57) | MTORPIK3CAPIK3CGPIK3CBPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120996-A1 | 5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |