Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 18/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.55 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.55 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.55 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3721950 | 0.93 | MTOR (0.57) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3725356 | 0.90 | MTOR (0.68) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3720834 | 0.85 | MTOR (0.61) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3729716 | 0.85 | MTOR (0.55) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3718606 | 0.84 | MTOR (0.60) | MTORPIK3CAPIK3CDPIK3R1 | |
| SCHEMBL3719933 | 0.84 | MTOR (0.69) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL2099033 | 0.82 | MTOR (0.74) | MTORPIK3CA | |
| SCHEMBL3721448 | 0.80 | MTOR (0.64) | MTORPIK3CAPIK3CGPIK3CD | |
| SCHEMBL1431049 | 0.79 | PIK3CA (0.69) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3722010 | 0.78 | MTOR (0.63) | MTORPIK3CAPIK3CGPIK3CBPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120996-A1 | 5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |