Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | USP1 | O94782 | 1/20 | 0.32 |
| ▸ | SDHB | P21912 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | NMT1 | P30419 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL117977 | 0.79 | BRD4 (0.36) | SCN9ABRD4LRRK2 | |
| SCHEMBL3719531 | 0.79 | LRRK2 (0.42) | SCN9ABRD4LRRK2 | |
| SCHEMBL3722905 | 0.78 | BRD4 (0.37) | SCN9ABRD4LRRK2 | |
| SCHEMBL3728805 | 0.78 | LRRK2 (0.41) | SCN9ABRD4MCL1LRRK2 | |
| SCHEMBL3720890 | 0.76 | LRRK2 (0.41) | SCN9ABRD4LRRK2 | |
| SCHEMBL3722934 | 0.76 | BRD4 (0.37) | SCN9ABRD4LRRK2 | |
| SCHEMBL3796268 | 0.76 | LRRK2 (0.40) | SCN9ABRD4LRRK2 | |
| SCHEMBL3727131 | 0.74 | LRRK2 (0.39) | SCN9ABRD4LRRK2 | |
| SCHEMBL3723882 | 0.74 | LRRK2 (0.39) | SCN9ABRD4LRRK2 | |
| SCHEMBL3721949 | 0.74 | SCN9A (0.35) | SCN9ABRD4LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125985-A1 | FUSED HETEROCYCLIC COMPOUND AND USE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-11-04 | — | — | WO | disclosed |