SCHEMBL3721093

SCHEMBL3721093

COc1nc(C(N)=O)cc(-c2ccc(C(F)(F)F)cc2)n1

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 13/20 0.53
ALDH1A1 P00352 2/20 0.47
HPGD P15428 2/20 0.47
GLA P06280 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
HSD17B10 Q99714 1/20 0.47
CASP1 P29466 1/20 0.46
FPR2 P25090 2/20 0.46
KDM4E B2RXH2 2/20 0.46
TP53 P04637 1/20 0.46
GAA P10253 1/20 0.46
ADORA3 P0DMS8 1/20 0.45
CYP1A2 P05177 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
KMT2A Q03164 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3717002 0.86 SCN9A (0.52) SCN9AALDH1A1HPGDNPSR1CASP1
SCHEMBL3728866 0.85 SCN9A (0.53) SCN9ACASP1FPR2KDM4ECYP1A2
SCHEMBL3717776 0.83 SCN9A (0.52) SCN9ASMN1; SMN2CASP1FPR2TP53
SCHEMBL3727410 0.82 SCN9A (0.53) SCN9ACASP1FPR2ADORA3KMT2A
SCHEMBL3725418 0.82 SCN9A (0.57) SCN9ACASP1FPR2ADORA3KMT2A
SCHEMBL3717917 0.81 SCN9A (0.53) SCN9ACASP1FPR2ADORA3KMT2A
SCHEMBL3724727 0.81 SCN9A (0.53) SCN9AALDH1A1HSD17B10CASP1FPR2
SCHEMBL3724700 0.80 SCN9A (0.51) SCN9ACASP1FPR2ADORA3KMT2A
SCHEMBL3720121 0.79 SCN9A (0.55) SCN9ACASP1FPR2KDM4EADORA3
SCHEMBL3721217 0.77 SCN9A (0.53) SCN9ACASP1FPR2ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US claimed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO claimed
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US disclosed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO disclosed