SCHEMBL3728866

SCHEMBL3728866

NC(=O)c1cc(-c2ccc(C(F)(F)F)cc2)nc(OCC(F)(F)F)n1

nearest known ligand 0.53

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 14/20 0.53
CASP1 P29466 1/20 0.44
KMT2A Q03164 1/20 0.43
PARP1 P09874 1/20 0.43
FPR2 P25090 2/20 0.42
KDM4E B2RXH2 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
LTB4R Q15722 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3717002 0.89 SCN9A (0.52) SCN9ACASP1FPR2KDM4E
SCHEMBL3717776 0.86 SCN9A (0.52) SCN9ACASP1FPR2
SCHEMBL3721093 0.85 SCN9A (0.53) SCN9ACASP1KMT2AFPR2KDM4E
SCHEMBL3722019 0.81 SCN9A (0.49) SCN9AKDM4E
SCHEMBL3721106 0.81 SCN9A (0.49) SCN9ACASP1KDM4E
SCHEMBL3725418 0.80 SCN9A (0.57) SCN9ACASP1KMT2APARP1FPR2
SCHEMBL3724677 0.79 SCN9A (0.51) SCN9A
SCHEMBL3717917 0.79 SCN9A (0.53) SCN9ACASP1KMT2APARP1FPR2
SCHEMBL3724727 0.79 SCN9A (0.53) SCN9ACASP1KMT2APARP1FPR2
SCHEMBL3728870 0.78 CTSS (0.42) SCN9ALTB4R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US claimed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO claimed
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US disclosed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO disclosed