SCHEMBL3717002

SCHEMBL3717002

CCOc1nc(C(N)=O)cc(-c2ccc(C(F)(F)F)cc2)n1

nearest known ligand 0.52

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 17/20 0.52
KDM4E B2RXH2 1/20 0.44
ALDH1A1 P00352 1/20 0.44
POLB P06746 1/20 0.44
MAPT P10636 1/20 0.44
HPGD P15428 1/20 0.44
AHR P35869 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
FPR2 P25090 2/20 0.43
CASP1 P29466 1/20 0.43
ADORA3 P0DMS8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3728866 0.89 SCN9A (0.53) SCN9AKDM4EFPR2CASP1
SCHEMBL3717776 0.87 SCN9A (0.52) SCN9AMAPTFPR2CASP1
SCHEMBL3721093 0.86 SCN9A (0.53) SCN9AKDM4EALDH1A1HPGDNPSR1
SCHEMBL3722019 0.80 SCN9A (0.49) SCN9AKDM4EALDH1A1HPGD
SCHEMBL3721106 0.80 SCN9A (0.49) SCN9AKDM4EALDH1A1HPGDCASP1
SCHEMBL3727410 0.79 SCN9A (0.53) SCN9AFPR2CASP1ADORA3
SCHEMBL3725418 0.79 SCN9A (0.57) SCN9AFPR2CASP1ADORA3
SCHEMBL3717005 0.79 CTSS (0.47) MAPTHPGDADORA3
SCHEMBL1734231 0.78 KDM4E (0.71) SCN9AKDM4EFPR2CASP1ADORA3
SCHEMBL3724677 0.78 SCN9A (0.51) SCN9APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US claimed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO claimed
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US disclosed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO disclosed