Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359762 | 0.84 | MEN1 (0.71) | MEN1KMT2ALMNACYP3A4ALDH1A1 | |
| SCHEMBL11554638 | 0.84 | MEN1 (0.66) | MEN1KMT2ALMNACYP3A4ALDH1A1 | |
| SCHEMBL28542980 | 0.82 | MEN1 (0.69) | MEN1KMT2ALMNACYP3A4ALDH1A1 | |
| SCHEMBL17028900 | 0.82 | LMNA (0.76) | MEN1KMT2ALMNACYP3A4ALDH1A1 | |
| SCHEMBL249305 | 0.82 | LMNA (0.76) | MEN1KMT2ALMNACYP3A4ALDH1A1 | |
| SCHEMBL31522633 | 0.81 | ACHE (0.58) | MEN1KMT2ALMNARAB9AACHE | |
| SCHEMBL27864663 | 0.81 | ACHE (0.58) | MEN1KMT2ALMNACYP3A4ALDH1A1 | |
| SCHEMBL20196268 | 0.81 | MEN1 (0.59) | MEN1KMT2ALMNACYP3A4ALDH1A1 | |
| SCHEMBL9480062 | 0.81 | MAPT (0.75) | MEN1KMT2ALMNACYP3A4ALDH1A1 | |
| SCHEMBL396146 | 0.81 | MEN1 (0.59) | MEN1KMT2ALMNACYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732543-B1 | TETRACYCLIC CARBOLINE DERATIVES FOR INHIBITING ANGIOGENESIS | PTC THERAPEUTICS INC (US) | 2017-05-10 | — | — | EP | disclosed |
| WO-2010123766-A1 | DIAMIDE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND β2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | THERAVANCE, INC. (US) | 2010-10-28 | — | — | WO | disclosed |