Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 3/20 | 0.46 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.42 |
| ▸ | STAT6 | P42226 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 3/20 | 0.40 |
| ▸ | CDK4 | P11802 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCND2 | P30279 | 1/20 | 0.40 |
| ▸ | CCNK | O75909 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3721125 | 0.87 | WEE1 (0.46) | WEE1TBK1LRRK2STAT6RAB9A | |
| SCHEMBL15163258 | 0.85 | TBK1 (0.50) | WEE1TBK1LRRK2STAT6AURKB | |
| SCHEMBL1284873 | 0.83 | STAT6 (0.55) | WEE1TBK1STAT6AURKACCND3 | |
| SCHEMBL1285153 | 0.83 | TBK1 (0.63) | WEE1TBK1LRRK2AURKBRAB9A | |
| SCHEMBL3713884 | 0.73 | CDK4 (0.48) | WEE1LRRK2CCND3CDK4CCND1 | |
| SCHEMBL3713891 | 0.72 | STAT6 (0.52) | WEE1TBK1STAT6AURKACCND3 | |
| SCHEMBL3790571 | 0.72 | STAT6 (0.68) | STAT6AURKAAURKBCCND3CDK4 | |
| SCHEMBL1285160 | 0.72 | WEE1 (0.40) | WEE1TBK1LRRK2STAT6RAB9A | |
| SCHEMBL3716704 | 0.70 | STAT6 (0.49) | WEE1TBK1STAT6AURKACCND3 | |
| SCHEMBL3717362 | 0.70 | STAT6 (0.53) | WEE1TBK1STAT6AURKACCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | claimed |
| WO-2010100431-A1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-09-10 | — | — | WO | claimed |
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | disclosed |
| WO-2010100431-A1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-09-10 | — | — | WO | disclosed |