SCHEMBL3721147

SCHEMBL3721147

NC(=O)c1cc(-c2ccc(C(F)(F)F)cc2)nc(-c2ccccc2C(F)(F)F)n1

nearest known ligand 0.50

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 14/20 0.50
SCN10A Q9Y5Y9 1/20 0.47
CYP2C9 P11712 2/20 0.44
SCN5A Q14524 1/20 0.44
KMO O15229 1/20 0.44
FPR2 P25090 2/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CASP1 P29466 1/20 0.43
ADORA3 P0DMS8 1/20 0.43
KDM4E B2RXH2 1/20 0.43
PARP1 P09874 1/20 0.42
MAOB P27338 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3725418 0.84 SCN9A (0.57) SCN9AFPR2CASP1ADORA3PARP1
SCHEMBL3718638 0.80 SCN9A (0.49) SCN9ACYP2C9SCN5AKMOFPR2
SCHEMBL3721217 0.80 SCN9A (0.53) SCN9AFPR2CASP1ADORA3PARP1
SCHEMBL3721149 0.79 USP1 (0.45) CYP2C9CYP2D6MAOB
SCHEMBL3717917 0.78 SCN9A (0.53) SCN9AFPR2CASP1ADORA3PARP1
SCHEMBL3724727 0.78 SCN9A (0.53) SCN9AFPR2CASP1ADORA3KDM4E
SCHEMBL3728860 0.77 SCN9A (0.56) SCN9AFPR2ADORA3PARP1
SCHEMBL3727410 0.77 SCN9A (0.53) SCN9AKMOFPR2CASP1ADORA3
SCHEMBL3720121 0.76 SCN9A (0.55) SCN9AFPR2CASP1ADORA3KDM4E
SCHEMBL3724700 0.74 SCN9A (0.51) SCN9AFPR2CASP1ADORA3PARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US claimed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO claimed
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US disclosed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO disclosed