SCHEMBL3721149

SCHEMBL3721149

NCc1cc(-c2ccc(C(F)(F)F)cc2)nc(-c2ccccc2C(F)(F)F)n1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP1 O94782 5/20 0.45
WDR48 Q8TAF3 5/20 0.45
DPP4 P27487 2/20 0.43
TOP1 P11387 2/20 0.41
CTSK P43235 2/20 0.41
CTSS P25774 1/20 0.41
BACE1 P56817 1/20 0.41
MAOB P27338 1/20 0.41
TOP2A P11388 1/20 0.40
EPHX2 P34913 1/20 0.39
PDE10A Q9Y233 1/20 0.39
TRPA1 O75762 1/20 0.39
TRPM8 Q7Z2W7 1/20 0.39
CYP1A2 P05177 2/20 0.38
CYP2D6 P10635 2/20 0.38
CHUK O15111 1/20 0.38
TXNRD1 Q16881 1/20 0.38
NOX4 Q9NPH5 1/20 0.38
CYP2C9 P11712 1/20 0.38
CLK4 Q9HAZ1 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3725421 0.83 DPP4 (0.50) DPP4TOP1CTSKCTSSMAOB
SCHEMBL3721147 0.79 SCN9A (0.50) MAOBCYP2D6CYP2C9
SCHEMBL3718641 0.78 DPP4 (0.47) DPP4CTSKCTSSMAOB
SCHEMBL3721220 0.78 KIF11 (0.51) DPP4TOP1CTSKCTSS
SCHEMBL3724728 0.77 KDM4E (0.49) DPP4TOP1CTSKCTSSMAOB
SCHEMBL3717919 0.77 CTSS (0.47) DPP4TOP1CTSKCTSSMAOB
SCHEMBL14393910 0.77 USP1 (0.44) USP1WDR48DPP4CTSKPDE10A
SCHEMBL3727413 0.76 CTSS (0.49) DPP4TOP1CTSKCTSSMAOB
SCHEMBL3720125 0.76 CTSS (0.46) DPP4TOP1CTSKCTSSMAOB
SCHEMBL893929 0.75 S1PR1 (0.51) DPP4TOP1CTSKCTSSEPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US claimed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO claimed
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US disclosed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO disclosed