Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.41 |
| ▸ | ATR | Q13535 | 6/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 6/20 | 0.41 |
| ▸ | ATRIP | Q8WXE1 | 6/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 6/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718193 | 1.00 | PIK3CD (0.42) | PIK3CDPIK3CBPIK3CACHEK1ATR | |
| SCHEMBL3555030 | 0.84 | PIK3CD (0.58) | PIK3CDPIK3CBPIK3CA | |
| SCHEMBL3716362 | 0.80 | KDM4E (0.50) | PIK3CDPIK3CBPIK3CACHEK1ATR | |
| SCHEMBL13050023 | 0.80 | KDM4E (0.50) | PIK3CDPIK3CBPIK3CACHEK1ATR | |
| SCHEMBL3714687 | 0.76 | PRKDC (0.41) | PIK3CDPIK3CBPIK3CA | |
| SCHEMBL13403441 | 0.73 | LMNA (0.37) | PIK3CDPIK3CBPIK3CA | |
| SCHEMBL23408531 | 0.72 | MTOR (0.42) | PIK3CDPIK3CACHEK1ATRPDCD1 | |
| SCHEMBL28577382 | 0.72 | ATR (0.43) | CHEK1ATRPDCD1ATRIPCD274 | |
| SCHEMBL29738240 | 0.72 | MTOR (0.42) | PIK3CDPIK3CACHEK1ATRPDCD1 | |
| SCHEMBL28584100 | 0.72 | MTOR (0.42) | PIK3CDPIK3CACHEK1ATRPDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010136778-A1 | DIBENZOTHIOPHENE DERIVATIVES AS DNA- PK INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010136778-A1 | DIBENZOTHIOPHENE DERIVATIVES AS DNA- PK INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2010-12-02 | — | — | WO | disclosed |