Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MPI | P34949 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 3/20 | 0.31 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | DRD5 | P21918 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3555030 | 0.75 | PIK3CD (0.58) | PRKDCPIK3CDPIK3CAPIK3CB | |
| SCHEMBL3718193 | 0.73 | PIK3CD (0.42) | PIK3CDPIK3CAPIK3CB | |
| SCHEMBL3721705 | 0.73 | PIK3CD (0.42) | PIK3CDPIK3CAPIK3CB | |
| SCHEMBL3714687 | 0.73 | PRKDC (0.41) | PRKDCPIK3CDPIK3CAPIK3CB | |
| SCHEMBL29241984 | 0.71 | LMNA (0.37) | LMNAKDM4EALDH1A1GLAGAA | |
| SCHEMBL10265840 | 0.68 | DRD2 (0.33) | DRD2DRD3ESR2DRD1DRD4 | |
| SCHEMBL8442883 | 0.68 | PSEN1 (0.35) | KDM4EALDH1A1DRD2DRD3DRD1 | |
| SCHEMBL15061745 | 0.66 | DRD2 (0.32) | DRD2DRD3ESR2DRD1DRD4 | |
| SCHEMBL588949 | 0.64 | DRD2 (0.31) | DRD2DRD3ESR2DRD1DRD4 | |
| SCHEMBL875453 | 0.64 | LMNA (0.44) | LMNAKDM4EALDH1A1GLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7696203-B2 | DNA-PK inhibitors | KUDOS PHARMACEUTICALS LIMITED (GB) | 2010-04-13 | — | — | US | disclosed |