Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 9/20 | 0.45 |
| ▸ | DRD3 | P35462 | 8/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3724363 | 0.84 | DRD2 (0.43) | GRM5DRD2DRD3KCNH2NPSR1 | |
| SCHEMBL3726056 | 0.80 | GRM5 (0.57) | GRM5DRD2NPSR1LMNAALDH1A1 | |
| SCHEMBL3110804 | 0.79 | GRM5 (0.59) | GRM5DRD2DRD3KCNH2NPSR1 | |
| SCHEMBL3110795 | 0.79 | GRM5 (0.59) | GRM5DRD2DRD3KCNH2NPSR1 | |
| SCHEMBL3722888 | 0.78 | GRM5 (0.48) | GRM5DRD2DRD3KCNH2NPSR1 | |
| SCHEMBL18490899 | 0.74 | NPC1 (0.61) | DRD2DRD3KCNH2CHRM1CHRM3 | |
| SCHEMBL17712859 | 0.73 | DRD2 (0.54) | DRD2DRD3KCNH2CHRM1CHRM3 | |
| SCHEMBL5479011 | 0.72 | KMT2A (0.44) | GRM5LMNAALDH1A1NPC1MEN1 | |
| SCHEMBL2897521 | 0.71 | ALOX12 (0.56) | DRD2DRD3NPSR1LMNAALDH1A1 | |
| SCHEMBL5741042 | 0.67 | MAPT (0.51) | LMNAALDH1A1RXFP1NPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010123451-A1 | SULPHIDE BRIDGED DERIVATIVES AS MODULATORS OF MGLUR5 | ASTRAZENECA AB (SE) | 2010-10-28 | — | — | WO | claimed |