SCHEMBL3721777

SCHEMBL3721777

CCC(CC)N1CCN(c2nc(CN)cc(-c3ccc(C(F)(F)F)cc3)n2)CC1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 6/20 0.42
HRH4 Q9H3N8 1/20 0.42
TRPV1 Q8NER1 1/20 0.41
CTSS P25774 1/20 0.40
CTSK P43235 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C19 P33261 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
KDM4E B2RXH2 4/20 0.40
MEN1 O00255 1/20 0.40
ALOX15 P16050 1/20 0.40
KMT2A Q03164 1/20 0.40
CYP11B2 P19099 2/20 0.39
HSD17B10 Q99714 3/20 0.38
ALDH1A1 P00352 2/20 0.38
MAPK1 P28482 2/20 0.38
TP53 P04637 1/20 0.38
HTR1A P08908 3/20 0.38
DRD2 P14416 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3718066 0.89 HRH4 (0.43) HRH4TRPV1CTSSCTSKCYP1A2
SCHEMBL3797918 0.86 HRH4 (0.44) HRH4TRPV1CTSSCTSKCYP1A2
SCHEMBL3724664 0.85 HRH4 (0.57) HRH4CYP1A2CYP2D6CYP2C19SMN1; SMN2
SCHEMBL3721072 0.83 CYP11B2 (0.46) HRH4TRPV1CTSSCTSKCYP1A2
SCHEMBL3721774 0.82 KDM4E (0.53) HRH3HRH4KDM4ECYP11B2HSD17B10
SCHEMBL3722161 0.82 HRH4 (0.53) HRH4CYP1A2CYP2D6CYP2C19SMN1; SMN2
SCHEMBL3720932 0.81 IDH2 (0.44) HRH4CTSSCTSKKDM4EKMT2A
SCHEMBL3725420 0.81 HSD17B10 (0.50) HRH4CYP1A2CYP2D6CYP2C19SMN1; SMN2
SCHEMBL3724014 0.79 HRH4 (0.43) HRH4TRPV1CTSSCTSKCYP1A2
SCHEMBL3717694 0.79 TSHR (0.43) HRH4CYP1A2CYP2D6CYP2C19SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US claimed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO claimed
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US disclosed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO disclosed