Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 8/20 | 0.62 |
| ▸ | BCR | P11274 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.54 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | F9 | P00740 | 1/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | PLAT | P00750 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3722117 | 0.89 | DYRK1A (0.62) | ABL1BCRKDM4EMAPTMAPK1 | |
| SCHEMBL1345700 | 0.89 | HTR2C (0.54) | ABL1BCRKDM4EMAPTMAPK1 | |
| SCHEMBL28105217 | 0.88 | KDR (0.58) | ABL1BCRKDM4EMAPTMAPK1 | |
| SCHEMBL3745780 | 0.86 | AURKA (0.67) | ABL1MAPTAURKATPX2PDK2 | |
| SCHEMBL25602455 | 0.85 | ABL1 (0.60) | ABL1BCRMAPTAURKATPX2 | |
| SCHEMBL8297933 | 0.84 | ABL1 (0.56) | ABL1BCRAURKATPX2CHEK1 | |
| SCHEMBL711132 | 0.82 | PARP1 (0.61) | ABL1BCRKDM4EMAPTMAPK1 | |
| SCHEMBL29448761 | 0.82 | PARP1 (0.61) | ABL1BCRKDM4EMAPTMAPK1 | |
| SCHEMBL3720366 | 0.81 | DHODH (0.50) | ABL1BCRKDM4EMAPTMAPK1 | |
| SCHEMBL3727314 | 0.81 | ABL1 (0.54) | ABL1BCRKDM4EMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | claimed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | claimed |
| CN-104334529-B | Compounds and compositions for inhibiting the activity of ABL1, ABL2, and BCR-ABL1 | 诺华股份有限公司 | 2017-03-15 | — | — | CN | disclosed |
| CN-104379574-B | For suppressing the heterocyclic carbamate derivatives of the activity of ABL1, ABL2 and BCR ABL1 | 诺华股份有限公司 | 2017-03-01 | — | — | CN | disclosed |
| CN-104379574-A | Benzamide derivatives for inhibiting the activity of ABL1, ABL 2 and BCR-ABL 1 | NOVARTIS AG | 2015-02-25 | — | — | CN | disclosed |
| CN-104334529-A | Compounds and compositions for inhibiting the activity of ABL1, ABL2, and BCR-ABL1 | NOVARTIS AG | 2015-02-04 | — | — | CN | disclosed |
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |