Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 6/20 | 0.60 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.56 |
| ▸ | BCR | P11274 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 2/20 | 0.50 |
| ▸ | FAAH | O00519 | 2/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | FAAH2 | Q6GMR7 | 1/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | XDH | P47989 | 1/20 | 0.49 |
| ▸ | ERN1 | O75460 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | TNKS | O95271 | 1/20 | 0.47 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.47 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL711132 | 0.90 | PARP1 (0.61) | DYRK1AABL1RIPK1BCRKDM4E | |
| SCHEMBL29448761 | 0.90 | PARP1 (0.61) | DYRK1AABL1RIPK1BCRKDM4E | |
| SCHEMBL3721809 | 0.89 | ABL1 (0.62) | DYRK1AABL1RIPK1BCRKDM4E | |
| Hydrochloric Acid SCHEMBL1268771 | 0.89 | PARP1 (0.59) | DYRK1AABL1RIPK1BCRKDM4E | |
| SCHEMBL5515377 | 0.86 | KMO (0.56) | SLC13A5 | |
| Trifluoroacetic Acid SCHEMBL12480668 | 0.84 | PARP1 (0.54) | DYRK1AABL1RIPK1BCRKDM4E | |
| SCHEMBL30837232 | 0.84 | ABL1 (0.55) | DYRK1AABL1MAPTXDHSLC6A7 | |
| SCHEMBL1347734 | 0.82 | RIPK1 (0.57) | DYRK1AABL1RIPK1BCRKDM4E | |
| Hydrochloric Acid SCHEMBL3341576 | 0.81 | RIPK1 (0.56) | DYRK1AABL1RIPK1BCRKDM4E | |
| SCHEMBL3727314 | 0.80 | ABL1 (0.54) | DYRK1AABL1RIPK1BCRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | claimed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | claimed |
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |