Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3721860 | 0.88 | HRH3 (0.66) | HRH3GPR119 | |
| SCHEMBL4937165 | 0.84 | HRH3 (0.69) | HRH3GPR119HDAC1HDAC6 | |
| SCHEMBL3736390 | 0.84 | HRH3 (0.69) | HRH3GPR119HDAC1HDAC6 | |
| SCHEMBL3809256 | 0.83 | HRH3 (0.60) | HRH3MEN1KMT2AHDAC1HDAC6 | |
| SCHEMBL3725967 | 0.83 | ALDH1A1 (0.55) | HRH3GPR119HTTSMN1; SMN2CYP11B1 | |
| SCHEMBL3725969 | 0.81 | HDAC1 (0.55) | HRH3MEN1KMT2ALMNAHDAC1 | |
| SCHEMBL4768843 | 0.80 | KDM4E (0.51) | GPR119HTTLMNATSHRNPSR1 | |
| SCHEMBL4943219 | 0.78 | USP30 (0.56) | HRH3HDAC1HDAC6 | |
| SCHEMBL4943222 | 0.78 | USP30 (0.56) | HRH3HDAC1HDAC6 | |
| SCHEMBL2792425 | 0.78 | MEN1 (0.60) | MEN1KMT2AGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155719-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | Wyeth LLC (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008147945-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-12-04 | — | — | WO | disclosed |