Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 3/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.46 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3725969 | 0.87 | HDAC1 (0.55) | HRH3HDAC1HDAC6LMNAUSP30 | |
| SCHEMBL4943222 | 0.84 | USP30 (0.56) | HRH3HDAC1HDAC6USP30 | |
| SCHEMBL4943219 | 0.84 | USP30 (0.56) | HRH3HDAC1HDAC6USP30 | |
| SCHEMBL3721859 | 0.83 | HRH3 (0.59) | HTTMAPK1HRH3HDAC1HDAC6 | |
| SCHEMBL3724630 | 0.83 | MMP7 (0.57) | ALDH1A1HTTNPC1MAPTMAPK1 | |
| SCHEMBL4937160 | 0.83 | HRH3 (0.53) | HTTHRH3BRD4HDAC1HDAC6 | |
| SCHEMBL3721860 | 0.81 | HRH3 (0.66) | HRH3GPR119USP30 | |
| SCHEMBL4768843 | 0.79 | KDM4E (0.51) | HTTLMNAGPR119 | |
| SCHEMBL7391868 | 0.79 | ALDH1A1 (0.67) | ALDH1A1HTTNPC1MAPTMAPK1 | |
| SCHEMBL3736390 | 0.78 | HRH3 (0.69) | HRH3HDAC1HDAC6GPR119USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155719-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | Wyeth LLC (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008147945-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-12-04 | — | — | WO | disclosed |