SCHEMBL3721909

SCHEMBL3721909

NC(=O)c1cccc(-c2ccc(N3CCCCC3)cc2)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.53
HPGD P15428 2/20 0.53
HSD17B10 Q99714 2/20 0.53
GAA P10253 2/20 0.53
KDM4E B2RXH2 1/20 0.53
MEN1 O00255 1/20 0.53
KMT2A Q03164 1/20 0.53
TNKS O95271 1/20 0.51
PARP1 P09874 1/20 0.51
PARP14 Q460N5 1/20 0.51
NPC1 O15118 4/20 0.50
RAB9A P51151 4/20 0.50
TP53 P04637 3/20 0.50
MAPT P10636 3/20 0.50
SMN1; SMN2 Q16637 3/20 0.50
TSHR P16473 2/20 0.50
TDP2 O95551 1/20 0.50
LMNA P02545 1/20 0.50
ALOX15 P16050 1/20 0.50
STAT1 P42224 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3722032 0.87 KMO (0.58) HPGDMEN1KMT2ATNKSPARP1
SCHEMBL3728008 0.86 AOC3 (0.57) ALDH1A1HSD17B10KDM4ETNKSPARP1
SCHEMBL30290422 0.84 GAA (0.72) ALDH1A1HPGDHSD17B10GAAKDM4E
SCHEMBL1397690 0.84 GAA (0.72) ALDH1A1HPGDHSD17B10GAAKDM4E
Hydrochloric Acid SCHEMBL4630423 0.83 GAA (0.70) ALDH1A1HPGDHSD17B10GAAKDM4E
SCHEMBL1397363 0.82 GAA (0.74) ALDH1A1HPGDHSD17B10GAAKDM4E
SCHEMBL1397421 0.79 NPC1 (0.61) ALDH1A1HPGDHSD17B10GAAKDM4E
SCHEMBL4767629 0.79 NPC1 (0.61) ALDH1A1HPGDHSD17B10GAAKDM4E
SCHEMBL4873981 0.79 NPC1 (0.61) ALDH1A1HPGDHSD17B10GAAKDM4E
SCHEMBL6999225 0.79 DHODH (0.63) HSD17B10PARP1MAPTTSHRTDP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US claimed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO claimed
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US disclosed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO disclosed