Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.37 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL943004 | 0.89 | HSD11B1 (0.44) | EPHX2 | |
| SCHEMBL945291 | 0.85 | EPHX2 (0.39) | TEAD1TEAD3DGAT1EPHX2GPR119 | |
| SCHEMBL946689 | 0.84 | GPR119 (0.45) | TEAD1TEAD3GPR119 | |
| SCHEMBL14097613 | 0.83 | GPR119 (0.36) | ITGB3ITGA2BTEAD1TEAD3GPR119 | |
| SCHEMBL14097819 | 0.78 | GPR119 (0.41) | TEAD1TEAD3GPR119 | |
| SCHEMBL238435 | 0.77 | GPR119 (0.44) | DGAT1EPHX2GPR119 | |
| SCHEMBL942710 | 0.76 | GPR119 (0.47) | TEAD1TEAD3GPR119 | |
| SCHEMBL943776 | 0.76 | TEAD1 (0.50) | ITGB3ITGA2BPKMTEAD1TEAD3 | |
| SCHEMBL946688 | 0.75 | MAPT (0.43) | EPHX2 | |
| SCHEMBL946687 | 0.74 | IDH1 (0.45) | EPHX2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146952-A1 | N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE | High Point Pharmaceuticals, LLC (US) | 2010-01-27 | — | — | EP | claimed |
| WO-2008101885-A1 | N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE | HIGH POINT PHARMACEUTICALS, LLC (US) | 2008-08-28 | — | — | WO | claimed |