Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 1/20 | 0.46 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10217134 | 0.86 | AVPR2 (0.51) | AVPR2AVPR1ASYKDRD2ATM | |
| SCHEMBL10217136 | 0.83 | AVPR2 (0.51) | AVPR2AVPR1ASYKDRD2ATM | |
| SCHEMBL10217138 | 0.83 | AVPR2 (0.50) | AVPR2AVPR1ASYKDRD2ATM | |
| SCHEMBL10217140 | 0.81 | AVPR2 (0.49) | AVPR2AVPR1ASYKDRD2ATM | |
| SCHEMBL256639 | 0.81 | DRD2 (0.46) | AVPR2AVPR1ASYKDRD2ATM | |
| SCHEMBL381756 | 0.79 | CTSA (0.51) | AVPR2AVPR1ACTSA | |
| SCHEMBL10217329 | 0.78 | AVPR2 (0.45) | AVPR2AVPR1ADRD2ATMPOLB | |
| SCHEMBL10216786 | 0.77 | AVPR2 (0.46) | AVPR2AVPR1ADRD2ATMPOLB | |
| SCHEMBL257267 | 0.77 | AVPR2 (0.45) | AVPR2AVPR1ADRD2ATMPOLB | |
| SCHEMBL19265249 | 0.76 | AVPR2 (0.45) | AVPR2AVPR1ASYKDRD2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125103-A1 | DIKETOPIPERAZINE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-11-04 | — | — | WO | disclosed |