Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.71 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.71 |
| ▸ | MTOR | P42345 | 15/20 | 0.66 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.59 |
| ▸ | JAK3 | P52333 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3730124 | 0.94 | PIK3CA (0.77) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL3722261 | 0.91 | MTOR (0.72) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL3721523 | 0.86 | PIK3CA (0.75) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL2369790 | 0.86 | PIK3CA (0.78) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL3722243 | 0.84 | PIK3CA (0.72) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL2370051 | 0.83 | PIK3CA (1.00) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL3722063 | 0.82 | PIK3CA (0.61) | PIK3CAMTORPIK3CG | |
| SCHEMBL13828894 | 0.82 | MTOR (0.78) | MTOR | |
| SCHEMBL3727361 | 0.82 | MTOR (0.73) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL2369449 | 0.82 | PIK3CA (0.85) | PIK3CAPIK3CDMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | claimed |
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |