Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.72 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.72 |
| ▸ | MTOR | P42345 | 15/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3722261 | 0.94 | MTOR (0.72) | PIK3CAPIK3CDMTORPIK3CGMAPT | |
| SCHEMBL3730124 | 0.90 | PIK3CA (0.77) | PIK3CAPIK3CDMTORPIK3CGMAPT | |
| SCHEMBL3721523 | 0.89 | PIK3CA (0.75) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL3727361 | 0.89 | MTOR (0.73) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL2369790 | 0.87 | PIK3CA (0.78) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL3722159 | 0.84 | PIK3CA (0.71) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL2369996 | 0.84 | PIK3CA (0.71) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL2370172 | 0.84 | PIK3CA (0.71) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL2370051 | 0.84 | PIK3CA (1.00) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL13828617 | 0.83 | MTOR (0.78) | MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | claimed |
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |