Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 15/20 | 0.72 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.68 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3722243 | 0.94 | PIK3CA (0.72) | MTORPIK3CAPIK3CDPIK3CGCYP1A2 | |
| SCHEMBL3722159 | 0.91 | PIK3CA (0.71) | MTORPIK3CAPIK3CDPIK3CG | |
| SCHEMBL13828802 | 0.86 | MTOR (0.79) | MTORPIK3CA | |
| SCHEMBL3723383 | 0.85 | MTOR (0.62) | MTORPIK3CAPIK3CDPIK3CG | |
| SCHEMBL3730124 | 0.85 | PIK3CA (0.77) | MTORPIK3CAPIK3CDPIK3CGMAPT | |
| SCHEMBL13718593 | 0.84 | MTOR (1.00) | MTOR | |
| SCHEMBL12463122 | 0.84 | MTOR (0.91) | MTOR | |
| SCHEMBL3721523 | 0.84 | PIK3CA (0.75) | MTORPIK3CAPIK3CDPIK3CG | |
| SCHEMBL2369790 | 0.84 | PIK3CA (0.78) | MTORPIK3CAPIK3CDPIK3CG | |
| SCHEMBL3727361 | 0.83 | MTOR (0.73) | MTORPIK3CAPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | claimed |
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |