SCHEMBL372216

SCHEMBL372216

Ic1cnc2ccccc2c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.57
PDGFRB P09619 4/20 0.50
PDGFRA P16234 4/20 0.50
MGAM O43451 1/20 0.50
ALDH1A1 P00352 4/20 0.48
GLA P06280 1/20 0.48
MAPT P10636 1/20 0.48
HPGD P15428 1/20 0.48
ACHE P22303 1/20 0.48
CYP2A6 P11509 1/20 0.47
BIRC5 O15392 1/20 0.46
KDM4E B2RXH2 1/20 0.45
GPR3 P46089 1/20 0.45
EGFR P00533 1/20 0.45
PIK3CD O00329 1/20 0.44
PIK3CA P42336 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
CYP11B1 P15538 1/20 0.43
CYP11B2 P19099 1/20 0.43
RAB9A P51151 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5349936 0.98 CYP1A2 (0.55) CYP1A2PDGFRBPDGFRAMGAMALDH1A1
Hydrochloric Acid SCHEMBL5349942 0.98 CYP1A2 (0.55) CYP1A2PDGFRBPDGFRAMGAMALDH1A1
Iodide SCHEMBL28754266 0.98 CYP1A2 (0.55) CYP1A2PDGFRBPDGFRAMGAMALDH1A1
SCHEMBL18848508 0.79 NOS1 (0.42) CYP1A2PDGFRBPDGFRAALDH1A1GLA
SCHEMBL30547068 0.78 PDGFRB (0.66) CYP1A2PDGFRBPDGFRACYP2A6BIRC5
SCHEMBL29060565 0.78 PDGFRB (0.66) CYP1A2PDGFRBPDGFRACYP2A6BIRC5
SCHEMBL18848507 0.77 ESR2 (0.41) CYP1A2PDGFRBPDGFRAMAPTEGFR
SCHEMBL32667946 0.76 PDGFRB (0.77) CYP1A2PDGFRBPDGFRAMGAMALDH1A1
SCHEMBL2772360 0.76 PDGFRB (0.77) CYP1A2PDGFRBPDGFRAMGAMALDH1A1
SCHEMBL272937 0.74 CYP1A2 (0.59) CYP1A2PDGFRBPDGFRAMGAMALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 177 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115057803-A S- (methyl-d) 3 ) Synthetic method and application of phenylether substances 杭州师范大学 2022-09-16 CN claimed
WO-2025016323-A1 PROTEIN ARGINASE METHYLTRANSFERASE-5 INHIBITOR AND MEDICAL USE THEREOF 江苏亚虹医药科技股份有限公司 2025-01-23 WO disclosed
CN-114736156-B Preparation method and application of sinomenine simplified derivative 中捷四方生物科技股份有限公司 2024-03-19 CN disclosed
CN-115057803-B S- (methyl-d) 3 ) Synthesis method and application of phenyl sulfide substance 杭州师范大学 2023-11-24 CN disclosed
US-11706983-B2 Organic light-emitting device SAMSUNG ELECTRONICS CO., LTD. (KR) 2023-07-18 US disclosed
CN-116377457-A Electrochemical synthesis method of halogenated quinoline-4 (1H) -ketone derivative 桂林理工大学 2023-07-04 CN disclosed
CN-115057803-A S- (methyl-d) 3 ) Synthetic method and application of phenylether substances 杭州师范大学 2022-09-16 CN disclosed
CN-111925324-B Synthetic method of 3-acyl quinoline compound 南通大学 2022-07-29 CN disclosed
CN-114736156-A Preparation method and application of simplified derivatives of cryptolepine 中捷四方生物科技股份有限公司 2022-07-12 CN disclosed
US-20220177443-A1 SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE DANA-FARBER CANCER INSTITUTE, INC. (US) 2022-06-09 US disclosed
CN-1088204-A 6-heptynoic acid and heptenoic acid compound SAGAMI CHEMICAL RESERCH CENTER (JP) 1994-06-22 CN disclosed
EP-0257518-B1 QUINOLINE-8-CARBOXYLIC ACID DERIVATIVES BASF Aktiengesellschaft (DE) 1992-01-02 EP disclosed
EP-0307519-B1 Perfluoroalkylation process ETHYL CORPORATION (US) 1991-04-17 EP disclosed
US-4889951-A Perfluoroalkylation process ETHYL CORPORATION (US) 1989-12-26 US disclosed
US-4822904-A Perfluoroalkylation process ETHYL CORPORATION (US) 1989-04-18 US disclosed
EP-0307519-A1 Perfluoroalkylation process ETHYL CORPORATION (US) 1989-03-22 EP disclosed
US-4814480-A Trifluoromethylation process ETHYL CORPORATION (US) 1989-03-21 US disclosed
US-4814482-A Trifluoromethylation process ETHYL CORPORATION (US) 1989-03-21 US disclosed
US-4808748-A Trifluoromethylation process ETHYL CORPORATION (US) 1989-02-28 US disclosed
EP-0257518-A1 Quinoline-8-carboxylic acid derivatives BASF Aktiengesellschaft (DE) 1988-03-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220177443-A1 SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE IKZF2, IKZF1, IKZF3 CYP1A2 1702/4885PDGFRB 3230/4885PDGFRA 3010/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.