Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 4/20 | 0.51 |
| ▸ | METAP1 | P53582 | 3/20 | 0.51 |
| ▸ | ANPEP | P15144 | 2/20 | 0.50 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.50 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3715879 | 1.00 | METAP2 (0.51) | METAP2METAP1ANPEPERAP1ERAP2 | |
| SCHEMBL3722287 | 1.00 | METAP2 (0.51) | METAP2METAP1ANPEPERAP1ERAP2 | |
| SCHEMBL3715948 | 1.00 | METAP2 (0.51) | METAP2METAP1ANPEPERAP1ERAP2 | |
| SCHEMBL7841524 | 1.00 | METAP2 (0.51) | METAP2METAP1ANPEPERAP1ERAP2 | |
| SCHEMBL6024122 | 0.89 | GRIK1 (0.49) | ANPEPERAP1ERAP2SLC6A2SLC6A4 | |
| SCHEMBL19079570 | 0.83 | TAAR1 (0.50) | METAP2METAP1ANPEPERAP1ERAP2 | |
| SCHEMBL13416403 | 0.83 | TAAR1 (0.50) | METAP2METAP1ANPEPERAP1ERAP2 | |
| SCHEMBL5556350 | 0.83 | ERAP1 (0.58) | METAP2METAP1ANPEPERAP1ERAP2 | |
| SCHEMBL2508068 | 0.83 | ANPEP (0.55) | METAP2METAP1ANPEPERAP1ERAP2 | |
| SCHEMBL4311417 | 0.83 | ANPEP (0.55) | METAP2METAP1ANPEPERAP1ERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100311798-A1 | 2-AMINOOXAZOLINES AS TAAR1 LIGANDS | HOFFMANN-LA ROCHE, INC. | 2010-12-09 | — | — | US | disclosed |
| WO-2010139707-A1 | 2-AMINOOXAZOLINES AS TAAR1 LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311798-A1 | 2-AMINOOXAZOLINES AS TAAR1 LIGANDS | TAAR1, TAAR5, NPY2R | METAP2 1040/4885METAP1 988/4885ANPEP 1415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.