Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL372612 | 0.81 | ALDH1A1 (0.54) | ALDH1A1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL372205 | 0.80 | ALDH1A1 (0.56) | ALDH1A1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL372238 | 0.74 | TRPV1 (0.41) | ALDH1A1KMT2AMEN1NPC1RAB9A | |
| Biphenyl SCHEMBL372236 | 0.73 | ALDH1A1 (0.67) | ALDH1A1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL372485 | 0.73 | ALDH1A1 (0.55) | ALDH1A1KMT2ARAB9ASMN1; SMN2TRPV1 | |
| SCHEMBL6881031 | 0.70 | ALDH1A1 (0.66) | ALDH1A1KMT2ARAB9ASMN1; SMN2ACACB | |
| Morpholine SCHEMBL372530 | 0.70 | ALDH1A1 (0.49) | ALDH1A1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL372200 | 0.69 | ALDH1A1 (1.00) | ALDH1A1NPC1RAB9ASMN1; SMN2ACACB | |
| SCHEMBL14294117 | 0.68 | ALDH1A1 (0.62) | ALDH1A1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6847857 | 0.67 | ALDH1A1 (0.65) | ALDH1A1KMT2ARAB9ASMN1; SMN2ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2261212-B1 | Preparation of quinoline-substituted carbamate derivatives | ABBVIE INC (US) | 2016-08-31 | — | — | EP | disclosed |
| EP-2409964-B1 | Process for the preparation of carbonate derivatives | ABBOTT LAB (US) | 2016-01-27 | — | — | EP | disclosed |
| EP-1192139-B1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | ABBOTT LAB (US) | 2012-04-18 | — | — | EP | disclosed |
| EP-2409964-A2 | Preparation of substituted carbonate and carbamate derivatives | Abbott Laboratories (US) | 2012-01-25 | — | — | EP | disclosed |
| EP-2261212-A2 | Preparation of quinoline-substituted carbonate and carbamate derivatives | Abbott Laboratories (US) | 2010-12-15 | — | — | EP | disclosed |
| US-7074932-B2 | Preparation of quinoline-substituted carbonate and carbamate derivatives | ABBVIE INC. | 2006-07-11 | — | — | US | disclosed |
| US-20060128962-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | ALLEN MICHAEL S | 2006-06-15 | — | — | US | disclosed |
| US-20030199696-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | ABBVIE INC. | 2003-10-23 | — | — | US | disclosed |
| US-6579986-B2 | Metal-catalyzed coupling reactions for 6-o-substituted macrolide antibiotics | ABBOTT LABORATORIES | 2003-06-17 | — | — | US | disclosed |
| US-20020165390-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | ABBVIE INC. | 2002-11-07 | — | — | US | disclosed |
| US-6417366-B2 | CHEMICAL INTERMEDIATE FOR MACROLACTONE ANTIBIOTIC | ABBOTT LABORATORIES | 2002-07-09 | — | — | US | disclosed |
| US-20020013468-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | ABBVIE INC. | 2002-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128962-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | CA7, CA6, CA4 | ALDH1A1 4601/4885KMT2A 567/4885MEN1 257/4885 |
| US-20030199696-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | CA7, CA6, CA4 | ALDH1A1 4601/4885KMT2A 567/4885MEN1 257/4885 |
| US-20020165390-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | CA7, CA6, CA4 | ALDH1A1 4601/4885KMT2A 567/4885MEN1 257/4885 |
| US-20020013468-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | CA7, CA6, CA4 | ALDH1A1 4601/4885KMT2A 567/4885MEN1 257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.