Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | PDCD1LG2 | Q9BQ51 | 4/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | PDE9A | O76083 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3719739 | 1.00 | MAPT (0.36) | MAPTKDM4EL3MBTL1GAACA12 | |
| SCHEMBL3719502 | 1.00 | MAPT (0.36) | MAPTKDM4EL3MBTL1GAACA12 | |
| SCHEMBL3719336 | 0.79 | KDM4E (0.38) | MAPTKDM4EL3MBTL1GAACD274 | |
| SCHEMBL3719504 | 0.75 | CA12 (0.39) | MAPTKDM4EL3MBTL1GAACA12 | |
| SCHEMBL3717464 | 0.72 | AOC3 (0.35) | PDCD1LG2CD274ADRB2ADRB1 | |
| SCHEMBL3717491 | 0.72 | AOC3 (0.35) | PDCD1LG2CD274ADRB2ADRB1 | |
| SCHEMBL10490374 | 0.71 | HSD17B10 (0.50) | MAPTKDM4EL3MBTL1KMT2AMEN1 | |
| SCHEMBL4950208 | 0.70 | P2RX7 (0.46) | — | |
| SCHEMBL22885900 | 0.70 | PDCD1LG2 (0.37) | MAPTKDM4EPDCD1LG2CD274KMT2A | |
| SCHEMBL11152408 | 0.69 | IDO1 (0.43) | MAPTKDM4EL3MBTL1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010132015-A1 | NEW COMPOUNDS MODULATING GAMMA-SECRETASE AND THEIR USE IN THE TREATMENT OF ALPHA BETA RELATED PATHOLOGIES, SUCH AS ALZHEIMER'S DISEASE | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | WO | disclosed |