Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.85 |
| ▸ | LMNA | P02545 | 1/20 | 0.85 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.85 |
| ▸ | MMP13 | P45452 | 1/20 | 0.85 |
| ▸ | HPGD | P15428 | 3/20 | 0.76 |
| ▸ | TSHR | P16473 | 2/20 | 0.76 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | AURKA | O14965 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | CRHBP | P24387 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5335238 | 0.92 | MEN1 (1.00) | MEN1KMT2ALMNAMAPK1MMP13 | |
| SCHEMBL5335082 | 0.87 | MEN1 (0.90) | MEN1KMT2ALMNAMAPK1MMP13 | |
| SCHEMBL5334358 | 0.87 | MEN1 (0.90) | MEN1KMT2ALMNAMAPK1MMP13 | |
| SCHEMBL4925396 | 0.87 | MEN1 (0.84) | MEN1KMT2ALMNAMAPK1MMP13 | |
| SCHEMBL108263 | 0.86 | ALDH1A1 (0.92) | MEN1KMT2ALMNAMAPK1MMP13 | |
| SCHEMBL5341210 | 0.82 | KMT2A (0.80) | MEN1KMT2ALMNAMAPK1MMP13 | |
| SCHEMBL5338191 | 0.82 | MEN1 (0.80) | MEN1KMT2ALMNAMAPK1MMP13 | |
| SCHEMBL2261349 | 0.81 | MEN1 (0.64) | MEN1KMT2ALMNAMAPK1MMP13 | |
| SCHEMBL5332989 | 0.81 | HPGD (0.83) | MEN1KMT2ALMNAMAPK1MMP13 | |
| SCHEMBL9416647 | 0.80 | ROCK2 (0.65) | MEN1KMT2ALMNAMAPK1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234995-A1 | LEUKOTRIENE B4 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009077385-A1 | LEUKOTRIENE B4 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | WO | disclosed |