Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.33 |
| ▸ | RBP4 | P02753 | 10/20 | 0.33 |
| ▸ | NAMPT | P43490 | 2/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.30 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27932368 | 0.76 | — | — | |
| SCHEMBL31459318 | 0.72 | CYP8B1 (0.42) | — | |
| SCHEMBL14289084 | 0.69 | — | — | |
| SCHEMBL2806211 | 0.68 | P2RX7 (0.32) | LMNAHSP90AA1 | |
| SCHEMBL29496182 | 0.67 | MKNK1 (0.43) | — | |
| SCHEMBL3479676 | 0.67 | DPP4 (0.41) | SMN1; SMN2DPP8CHRM4 | |
| SCHEMBL8204875 | 0.67 | KDM4E (0.34) | HSD17B10 | |
| SCHEMBL22390113 | 0.67 | P2RX7 (0.36) | — | |
| SCHEMBL14931531 | 0.66 | TRPV1 (0.41) | — | |
| SCHEMBL1497198 | 0.66 | P2RX7 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010131145-A1 | CYCLOBUTENEDIONE DERIVATIVES | PFIZER LIMITED (GB) | 2010-11-18 | — | — | WO | disclosed |
| WO-2010131147-A1 | CYCLOBUTENEDIONE DERIVATIVES | PFIZER LIMITED (GB) | 2010-11-18 | — | — | WO | disclosed |
| WO-2010131146-A1 | CYCLOBUTENEDIONE DERIVATIVES | PFIZER LIMITED (GB) | 2010-11-18 | — | — | WO | disclosed |