Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | SORD | Q00796 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.30 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.30 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.30 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.30 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17624117 | 0.76 | USP2 (0.36) | ALDH1A1HSD17B10GRIN2DGRIN3BCHRM1 | |
| SCHEMBL2806211 | 0.74 | P2RX7 (0.32) | CYP1A2CYP3A4CLK4 | |
| SCHEMBL22582925 | 0.73 | UCHL1 (0.33) | KDM4EALDH1A1 | |
| SCHEMBL13223182 | 0.72 | ATM (0.33) | — | |
| SCHEMBL8194629 | 0.72 | NOTUM (0.41) | KDM4EALDH1A1NOTUMMEN1KMT2A | |
| SCHEMBL7946982 | 0.67 | TRAP1 (0.52) | ALDH1A1NOTUMMEN1KMT2ACYP3A4 | |
| SCHEMBL3722963 | 0.67 | LMNA (0.34) | HSD17B10 | |
| SCHEMBL16269004 | 0.67 | NOTUM (0.39) | KDM4ENOTUMMEN1KMT2ANLRP3 | |
| SCHEMBL28886631 | 0.66 | KDM4E (0.31) | KDM4EALDH1A1 | |
| SCHEMBL8193162 | 0.65 | NAMPT (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033389-A2 | MACROCYCLIC HCV INHIBITORS AND THEIR USES | NOVARTIS AG (CH) | 2008-03-20 | — | — | WO | disclosed |