Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 5/20 | 0.39 |
| ▸ | NAPEPLD | Q6IQ20 | 6/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3722970 | 0.74 | AKT1 (0.51) | KMT2ACYP1A2CYP2D6MAPTRAF1 | |
| SCHEMBL29023026 | 0.72 | GPR119 (0.47) | MAPT | |
| SCHEMBL16094927 | 0.72 | CYP1A2 (0.60) | KMT2ACYP1A2CYP2D6MAPTRAF1 | |
| SCHEMBL23505799 | 0.72 | CYP1A2 (0.54) | KMT2ACYP1A2CYP2D6MAPTRAF1 | |
| SCHEMBL18153347 | 0.72 | PIK3CA (0.53) | KMT2ACYP1A2CYP2D6MAPTPIK3CA | |
| SCHEMBL29434915 | 0.72 | PIK3CA (0.53) | KMT2ACYP1A2CYP2D6MAPTPIK3CA | |
| SCHEMBL3997637 | 0.72 | PIK3CA (0.53) | KMT2ACYP1A2CYP2D6MAPTPIK3CA | |
| SCHEMBL244726 | 0.71 | PIK3CA (0.40) | KMT2APIK3CAGAA | |
| SCHEMBL3605038 | 0.71 | USP2 (0.48) | KMT2ACYP1A2CYP2D6MAPTPIK3CA | |
| SCHEMBL3115454 | 0.70 | PIK3CA (0.39) | KMT2APIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146981-A1 | PHARMACEUTICAL COMPOUNDS | F. Hoffmann-Roche AG (CH) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008125833-A1 | PHARMACEUTICAL COMPOUNDS | PIRAMED LIMITED (GB) | 2008-10-23 | — | — | WO | disclosed |