Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | POLA1 | P09884 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | AGPAT2 | O15120 | 3/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1193784 | 0.85 | MAPT (0.50) | KMT2APOLA1MAPTSMN1; SMN2POLB | |
| SCHEMBL3719304 | 0.83 | KMT2A (0.72) | KMT2APOLA1MAPTSMN1; SMN2POLB | |
| SCHEMBL14050066 | 0.78 | POLA1 (0.61) | KMT2APOLA1MAPTSMN1; SMN2POLB | |
| SCHEMBL29608945 | 0.78 | POLA1 (0.61) | KMT2APOLA1MAPTSMN1; SMN2POLB | |
| SCHEMBL18971579 | 0.76 | CHRNA7 (0.47) | KMT2ASMN1; SMN2POLBGAANPC1 | |
| SCHEMBL3233125 | 0.75 | MAPT (0.70) | KMT2APOLA1MAPTSMN1; SMN2POLB | |
| SCHEMBL16380596 | 0.75 | POLA1 (0.75) | KMT2APOLA1MAPTSMN1; SMN2POLB | |
| SCHEMBL1320467 | 0.75 | KMT2A (0.66) | KMT2APOLA1MAPTSMN1; SMN2POLB | |
| SCHEMBL7741592 | 0.73 | POLA1 (0.62) | KMT2APOLA1MAPTSMN1; SMN2POLB | |
| SCHEMBL12346224 | 0.73 | POLA1 (0.62) | KMT2APOLA1MAPTSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120854-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-10-21 | — | — | WO | disclosed |
| WO-2010120854-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-10-21 | — | — | WO | disclosed |