Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 5/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | ESRRA | P11474 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3722836 | 0.92 | PDE4B (0.46) | ACACBPDE4BESRRACREBBPMAPT | |
| SCHEMBL3721612 | 0.91 | PDE4B (0.52) | ACACBPDE4BESRRACREBBPMAPT | |
| SCHEMBL3721012 | 0.89 | PDE4B (0.45) | ACACBPDE4BESRRAMAPTTHRB | |
| SCHEMBL3721408 | 0.87 | PDE4B (0.47) | PDE4BCREBBPALDH1A1L3MBTL1MEN1 | |
| SCHEMBL3720427 | 0.87 | ACACB (0.56) | ACACBPDE4BESRRAPPARA | |
| SCHEMBL3723036 | 0.86 | PDE4B (0.51) | PDE4BESRRACREBBPMAPTTHRB | |
| SCHEMBL3720457 | 0.86 | PDE4B (0.48) | ACACBPDE4BESRRAMAPTALDH1A1 | |
| SCHEMBL3726992 | 0.85 | ESRRA (0.53) | ACACBESRRACREBBPMAPTALDH1A1 | |
| SCHEMBL3723075 | 0.81 | ACACB (0.57) | ACACB | |
| SCHEMBL3723076 | 0.81 | MTNR1A (0.50) | ACACBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |