SCHEMBL3723974

SCHEMBL3723974

O=C(O)c1cccc(C#Cc2ccccn2)c1Cl

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 1/20 0.49
LMNA P02545 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
TSHR P16473 2/20 0.44
FFAR1 O14842 1/20 0.43
GRM5 P41594 3/20 0.42
KDM4E B2RXH2 3/20 0.40
TDP1 Q9NUW8 1/20 0.40
HAO1 Q9UJM8 2/20 0.40
L3MBTL1 Q9Y468 2/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
ALDH1A1 P00352 2/20 0.39
CYP3A4 P08684 1/20 0.39
MAPT P10636 1/20 0.39
ALOX15 P16050 1/20 0.39
BLM P54132 1/20 0.39
AGER Q15109 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
PKM P14618 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4066718 0.86 PTGDR2 (0.48) PTGDR2LMNASMN1; SMN2TSHRFFAR1
SCHEMBL4189309 0.77 FFAR1 (0.41) PTGDR2LMNASMN1; SMN2TSHRFFAR1
SCHEMBL4325937 0.77 PTGDR2 (0.44) PTGDR2FFAR1GRM5HAO1MEN1
SCHEMBL10411944 0.76 TSHR (0.57) LMNASMN1; SMN2TSHRKDM4EMEN1
SCHEMBL3641138 0.76 NPC1 (0.58) PTGDR2TSHRFFAR1GRM5KDM4E
SCHEMBL30526535 0.74 GRM5 (0.57) GRM5KCNH2
SCHEMBL16004606 0.74 GRM5 (0.57) GRM5KCNH2
SCHEMBL3412343 0.73 PTGDR2 (0.51) PTGDR2TSHRFFAR1GRM5KDM4E
SCHEMBL1921319 0.73 GRM5 (0.57) PTGDR2GRM5TDP1KCNH2
SCHEMBL13517269 0.71 FFAR1 (0.41) PTGDR2LMNASMN1; SMN2TSHRFFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010124047-A1 BISARYL ALKYNYLAMIDES AS NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 5 (MGLUR5) WYETH LLC (US) 2010-10-28 WO disclosed