Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 5/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.36 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4066718 | 0.80 | PTGDR2 (0.48) | PTGDR2FFAR1HAO1GRM5MEN1 | |
| SCHEMBL3723974 | 0.77 | PTGDR2 (0.49) | PTGDR2FFAR1HAO1GRM5MEN1 | |
| SCHEMBL31475510 | 0.77 | GRM5 (0.40) | PTGDR2SYKTAS2R14GRM5MEN1 | |
| SCHEMBL3411039 | 0.75 | PTGDR2 (0.51) | PTGDR2FFAR1HAO1SYKGRM5 | |
| SCHEMBL31475533 | 0.73 | TAS2R14 (0.36) | PTGDR2HAO1SYKTAS2R14GRM5 | |
| SCHEMBL31475549 | 0.72 | HAO1 (0.42) | HAO1 | |
| SCHEMBL3641138 | 0.70 | NPC1 (0.58) | PTGDR2FFAR1GRM5ALDH1A1MAPT | |
| SCHEMBL16004606 | 0.68 | GRM5 (0.57) | GRM5 | |
| SCHEMBL30526535 | 0.68 | GRM5 (0.57) | GRM5 | |
| SCHEMBL12492897 | 0.68 | ALB (0.52) | SYKTAS2R14MEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143404-A1 | PIPERAZINE METABOTROPIC GLUTAMATE RECEPTOR 5 (MGLUR5) NEGATIVE ALLOSTERIC MODULATORS FOR ANXIETY/DEPRESSION | WYETH (US) | 2009-11-26 | — | — | WO | disclosed |