Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.44 |
| ▸ | CES1 | P23141 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5393793 | 0.91 | CES2 (0.55) | CES2CES1DNM1 | |
| SCHEMBL2227136 | 0.91 | CES2 (0.55) | CES2CES1DNM1 | |
| SCHEMBL28339868 | 0.91 | CES2 (0.55) | CES2CES1DNM1 | |
| SCHEMBL28430028 | 0.91 | CES2 (0.55) | CES2CES1DNM1 | |
| SCHEMBL31399648 | 0.91 | CES2 (0.55) | CES2CES1DNM1 | |
| SCHEMBL16782313 | 0.91 | CES2 (0.55) | CES2CES1DNM1 | |
| SCHEMBL27141492 | 0.91 | CES2 (0.55) | CES2CES1DNM1 | |
| SCHEMBL5401819 | 0.91 | CES2 (0.55) | CES2CES1DNM1 | |
| SCHEMBL10603119 | 0.91 | CES2 (0.55) | CES2CES1DNM1 | |
| SCHEMBL678577 | 0.91 | CES2 (0.55) | CES2CES1DNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2235007-A1 | 6H-DIBENZ0 [B, E] OXEPINE DERIVED NONSTEROIDAL MINERALOCORTICOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009085584-A1 | 6H-DIBENZ0 [B, E] OXEPINE DERIVED NONSTEROIDAL MINERALOCORTICOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2009-07-09 | — | — | WO | disclosed |